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A Selective and Benign Synthesis of Functionalized Benzalacetones via Mizoroki–Heck Reaction Using Aryldiazonium Salts
Author(s) -
Stern Therese,
Rückbrod Sven,
Czekelius Constantin,
Donner Constanze,
Brunner Heiko
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900868
Subject(s) - chemistry , heck reaction , palladium , catalysis , organic chemistry , combinatorial chemistry
Palladium‐catalyzed Mizoroki–Heck reactions were carried out in the presence of calcium carbonate in alcoholic solvents. Under these conditions an efficient preparation of functionalized benzalacetones was developed. The reactions were carried out at room temperature and aerobic conditions, giving the products within several minutes in up to 95% isolated yields. Furthermore, some kinetic investigations, mechanistic insights and considerations are presented.