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A Highly Selective, Polymer‐Supported Organocatalyst for Michael Additions with Enzyme‐Like Behavior
Author(s) -
Alza Esther,
Pericàs Miquel A.
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900817
Subject(s) - chemistry , silyl ether , michael reaction , catalysis , substrate (aquarium) , linker , selectivity , polymer , combinatorial chemistry , ether , silylation , organic chemistry , homogeneous , organocatalysis , polymer chemistry , enantioselective synthesis , oceanography , physics , computer science , thermodynamics , operating system , geology
A polymer‐supported α,α‐diarylprolinol silyl ether displays catalytic activity and enantioselectivity comparable to the best homogeneous catalysts in the Michael addition of aldehydes to nitroolefins. Above all, the combination of polymer backbone, triazole linker, and catalytic unit confers to it an unprecedented substrate selectivity in favor of linear, short‐chain aldehydes.