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Asymmetric Synthesis with Silicon‐Based Bulky Amino Organocatalysts
Author(s) -
Xu LiWen,
Li Li,
Shi ZhiHui
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900797
Subject(s) - chemistry , organocatalysis , iminium , stereoselectivity , organosilicon , silylation , moiety , aldol reaction , catalysis , enantioselective synthesis , atom economy , combinatorial chemistry , organic chemistry , silicon
Recent years have witnessed an explosive growth in the field of amino organocatalysis, especially in asymmetric enamine and iminium catalysis. Except for the obvious interaction between organocatalyst and substrate, the impact of bulky side group ons stereoselectivity is not as simple as one could imagine. Within the development of bulky site‐stereoselective organocatalysts, functional silyl organocatalysts with a bulky silicon group are promising and meet the high standards of modern synthetic methods. This review focuses on the recent advances in the synthetic applications of silicon‐based, bulky amino organocatalysts in which catalysts containing an organosilicon moiety or group play a formative role in controlling both the course of the reaction as well as the stereoselectivity.