Copper‐Catalyzed Highly Regioselective Oxidative CH Bond Amidation of 2‐Arylpyridine Derivatives and 1‐Methylindoles | Zendy

Shuai Qi | Zendy; Deng Guojun | Zendy; Chua Zhijie | Zendy; Bohle D. Scott | Zendy; Li ChaoJun | Zendy

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Copper‐Catalyzed Highly Regioselective Oxidative CH Bond Amidation of 2‐Arylpyridine Derivatives and 1‐Methylindoles

Author(s) -

Shuai Qi,

Deng Guojun,

Chua Zhijie,

Bohle D. Scott,

Li ChaoJun

Publication year - 2010

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200900775

Subject(s) - chemistry , regioselectivity , catalysis , halide , bromide , aryl , copper , oxidative addition , peroxide , ligand (biochemistry) , medicinal chemistry , oxidative phosphorylation , combinatorial chemistry , organic chemistry , biochemistry , alkyl , receptor

Copper(I) bromide‐catalyzed amidation of 2‐arylpyridine derivatives and 1‐methylindoles with a variety of amides was achieved by employing tert ‐butyl peroxide (TBP) as oxidant. Aryl halides could be tolerated under the reaction conditions. Neither a special ligand nor a base was required for this amidation process.

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