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Copper‐Catalyzed Highly Regioselective Oxidative CH Bond Amidation of 2‐Arylpyridine Derivatives and 1‐Methylindoles
Author(s) -
Shuai Qi,
Deng Guojun,
Chua Zhijie,
Bohle D. Scott,
Li ChaoJun
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900775
Subject(s) - chemistry , regioselectivity , catalysis , halide , bromide , aryl , copper , oxidative addition , peroxide , ligand (biochemistry) , medicinal chemistry , oxidative phosphorylation , combinatorial chemistry , organic chemistry , biochemistry , alkyl , receptor
Copper(I) bromide‐catalyzed amidation of 2‐arylpyridine derivatives and 1‐methylindoles with a variety of amides was achieved by employing tert ‐butyl peroxide (TBP) as oxidant. Aryl halides could be tolerated under the reaction conditions. Neither a special ligand nor a base was required for this amidation process.