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Copper(I) Acetate: A Structurally Simple but Highly Efficient Dinuclear Catalyst for Copper‐Catalyzed Azide‐Alkyne Cycloaddition
Author(s) -
Shao Changwei,
Cheng Guolin,
Su Deyong,
Xu Jimin,
Wang Xinyan,
Hu Yuefei
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900768
Subject(s) - cycloaddition , alkyne , chemistry , azide , catalysis , copper , acetic acid , combinatorial chemistry , organic chemistry , medicinal chemistry , polymer chemistry
Abstract In this article, the structurally well‐defined dinuclear complex copper(I) acetate was studied in detail and was developed as a highly practical and efficient catalyst for the copper(I)‐catalyzed azide‐alkyne cycloaddition. The “bare” phenylethynylcopper(I) (i.e., with no exogeneous ligands) was isolated as an intermediate, which can be converted into an active catalytic species by treatment with acetic acid ( in situ produced in the reaction) to efficiently catalyze the azide‐alkyne cycloaddition under mild conditions.