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Microwave‐Assisted Synthesis of N‐Heterocyclic Carbene‐ Palladium(II) Complexes
Author(s) -
Winkelmann Ole H.,
Navarro Oscar
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900749
Subject(s) - carbene , chemistry , palladium , medicinal chemistry , catalysis , organic chemistry , combinatorial chemistry
The microwave‐assisted synthesis of two different types of N‐heterocyclic carbene‐palladium(II) complexes, (NHC)Pd(acac)Cl (NHC=N‐heterocyclic carbene; acac=acetylacetonate) and (NHC)PdCl 2 (3‐chloropyridine), has been carried out. A drastic reduction in reaction times (20 to 88 times faster, depending on the complex) was observed when compared to the previously described, conventionally‐heated synthesis of these complexes. The protocol also allowed for the synthesis of (IPr)Pd(acac)Cl [IPr=1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene] on a 5‐mmol scale in 30 min, with the reactants loaded in air.