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A Novel Strategy for the Construction of Functionalized 1,5‐ Benzodiazepines via a Tandem Conjugated Addition/Cyclization Process
Author(s) -
Li Jian,
Li Shaoyu,
Li Chunju,
Liu Yuejin,
Jia Xueshun
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900736
Subject(s) - chemistry , conjugated system , tandem , combinatorial chemistry , process (computing) , organic chemistry , polymer , materials science , computer science , composite material , operating system
A novel approach for the synthesis of functionalized 1,5‐benzodiazepine is described. The protocol is triggered by a tandem conjugated addition/cyclization process from the readily available starting materials 1,2‐phenylenediamine and ethyl propiolate. The products have secondary amino and ester groups, and a β‐enamino ester, which can serve in further functionalizations to produce molecular diversity.
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