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Gold(I)‐Catalyzed One‐Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo‐/Pyrido[2,1‐ b ]benzo[ d ][1,3]oxazin‐ 1‐ones
Author(s) -
Zhou Yu,
Zhai Yun,
Ji Xun,
Liu Guannan,
Feng Enguang,
Ye Deju,
Zhao Linxiang,
Jiang Hualiang,
Liu Hong
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900724
Subject(s) - chemistry , tandem , catalysis , combinatorial chemistry , ring (chemistry) , one pot synthesis , stereochemistry , coupling (piping) , reaction conditions , medicinal chemistry , organic chemistry , mechanical engineering , materials science , engineering , composite material
A highly efficient method has been developed for the one‐pot synthesis of multi‐ring heterocyclic compounds such as pyrrolo‐/pyrido[2,1‐ b ]benzo[ d ][1,3]oxazin‐1‐ones from o ‐aminobenzyl alcohols via a gold(I)‐catalyzed tandem coupling/cyclization reaction. Significantly, the strategy presents a straightforward and efficient approach to construct novel tricyclic or polycyclic molecular architectures in which two new CN bonds and one CO bond are formed in a one‐pot reaction operation from two simple starting materials. Moreover, a broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields.