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Highly Efficient Copper‐Catalyzed Synthesis of Internal Alkynes via Aerobic Oxidative Arylation of Terminal Alkynes
Author(s) -
Rao Honghua,
Fu Hua,
Jiang Yuyang,
Zhao Yufen
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900723
Subject(s) - chemistry , catalysis , copper , oxidative coupling of methane , stoichiometry , oxidative phosphorylation , combinatorial chemistry , ligand (biochemistry) , functional group , terminal (telecommunication) , oxygen , organic chemistry , biochemistry , polymer , receptor , telecommunications , computer science
We have developed a novel and highly efficient, copper‐catalyzed synthesis of internal alkynes via oxidative couplings of aromatic boronic acids with terminal alkynes at room temperature. The protocol uses inexpensive copper(I) oxide [Cu 2 O] as the catalyst, oxygen in the air as the stoichiometric oxidant; no ligand and sealed reaction vessels are required, and remarkable functional group tolerability is observed with coupling occurring.