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Phase‐Transfer‐Catalyzed Intramolecular Cyclization of ortho ‐Alkynyl Phenyl Ether Derivatives for Synthesis of 2,3‐Disubstituted Benzo[ b ]furans
Author(s) -
Hu Jie,
Wu LuYong,
Wang XiangChuan,
Hu YuanYuan,
Niu YanNing,
Liu XueYuan,
Yang Shangdong,
Liang YongMin
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900649
Subject(s) - chemistry , catalysis , isomerization , intramolecular force , reagent , combinatorial chemistry , ether , phase (matter) , organic chemistry , medicinal chemistry
Abstract A variety of substituted benzo[ b ]furans are readily prepared in good to excellent yields under the mild reaction conditions from o ‐(1‐alkynylphenoxy)‐1‐phenylethanone under phase‐transfer catalysis (PTC). This methodology accommodates simple experimental operations, inexpensive and environmentally benign catalysts, metal catalyst‐free conditions, facile reagents and the possibility to conduct large‐scale preparations. The development of carbon‐carbon bond formation processes via an overall structural isomerization represents the most atom‐economical approach.