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Ligand‐Free and Heterogeneous Palladium on Carbon‐Catalyzed Hetero‐Suzuki–Miyaura Cross‐Coupling
Author(s) -
Kitamura Yoshiaki,
Sako Satoko,
Tsutsui Azusa,
Monguchi Yasunari,
Maegawa Tomohiro,
Kitade Yukio,
Sajiki Hironao
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900638
Subject(s) - chemistry , palladium , alicyclic compound , ligand (biochemistry) , catalysis , coupling reaction , suzuki reaction , carbon fibers , combinatorial chemistry , organic chemistry , polymer chemistry , biochemistry , materials science , receptor , composite number , composite material
A ligand‐free and heterogeneous palladium on carbon (Pd/C)‐catalyzed hetero‐Suzuki–Miyaura coupling reaction has been developed. The protocol enables the construction of both heterocyclic‐alicyclic and heterocyclic‐heterocyclic biaryl derivatives in good to excellent yields. Furthermore, Pd/C could be reused. The time‐course study clarified that palladium was leached into the reaction media as the reaction proceeded and then completely deposited on the carbon support.