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Organocatalytic Asymmetric Synthesis of Protected α,β‐Diamino Acids
Author(s) -
Shi Zugui,
Yu Peiyuan,
Chua Pei Juan,
Zhong Guofu
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900580
Subject(s) - chemistry , enantioselective synthesis , organocatalysis , catalysis , organic chemistry , combinatorial chemistry , tosyl
In the presence of the readily available quinine‐derived catalyst 4d , highly diastereo‐ and enantioselective Mannich reactions of tosyl‐protected imines and α‐isothiocyanato imides proceeded to afford the protected α,β‐diamino acids, useful building blocks for natural products and biologically active compounds, in good to excellent yields.