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Efficient Method for the Synthesis of Optically Active 2‐Amino‐2‐chromene Derivatives via One‐Pot Tandem Reactions
Author(s) -
Xie JianWu,
Huang Xiong,
Fan LiPing,
Xu DongCheng,
Li XinSheng,
Su Hong,
Wen YiHang
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900579
Subject(s) - chemistry , malononitrile , tandem , optically active , cascade reaction , combinatorial chemistry , catalysis , organic chemistry , reaction conditions , hydrogen phosphate , phosphate , materials science , composite material
The asymmetric synthesis of functionalized 2‐amino‐2‐chromene derivatives with high enantioselectivities via one‐pot tandem reactions of functionalized α,β‐unsaturated ketones with malononitrile catalyzed by 9‐amino‐9‐deoxyepiquinine ( 1a ) in combination with ( R )‐1,1′‐binaphth‐2,2′‐diyl hydrogen phosphate ( 1c ) is reported for the first time.