Synthesis of Selectively Mono‐N‐Arylated Aliphatic Diamines  via  Iridium‐Catalyzed Amine Alkylation | Zendy

Blank Benoît | Zendy; Michlik Stefan | Zendy; Kempe Rhett | Zendy

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Synthesis of Selectively Mono‐N‐Arylated Aliphatic Diamines via Iridium‐Catalyzed Amine Alkylation

Author(s) -

Blank Benoît,

Michlik Stefan,

Kempe Rhett

Publication year - 2009

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200900548

Subject(s) - chemistry , iridium , catalysis , aminopyridines , amine gas treating , alkylation , ligand (biochemistry) , organic chemistry , diamine , amino esters , combinatorial chemistry , biochemistry , receptor

A highly selective phosphorus/nitrogen (P,N) ligand‐based iridium catalyst system efficiently catalyzes the reaction of arylamines with unprotected amino alcohols, yielding N‐arylated aliphatic diamines in yields of up to 93%. The reaction can be performed with a wide variety of branched and linear amino alcohols in combination with various aminopyridines or substituted anilines.

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