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Highly Efficient Synthesis of Quaternary α‐Hydroxy Phosphonates via Lewis Acid‐Catalyzed Hydrophosphonylation of Ketones
Author(s) -
Zhou Xin,
Liu Yanling,
Chang Lu,
Zhao Jiannan,
Shang Deju,
Liu Xiaohua,
Lin Lili,
Feng Xiaoming
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900531
Subject(s) - chemistry , lewis acids and bases , ketone , catalysis , enantioselective synthesis , organic chemistry , schiff base , titanium , lewis acid catalysis , combinatorial chemistry , polymer chemistry
A Lewis acid catalyst has been first applied to the hydrophosphonylation of ketones, giving the corresponding quaternary α‐hydroxy phosphonates in high yields (up to 98%). The present method was highly tolerable for functionalized ketones. Moreover, the first catalytic enantioselective hydrophosphonylation of an unactivated ketone was also realized by using a tridentate Schiff base‐titanium complex.