Highly Efficient Synthesis of Quaternary α‐Hydroxy Phosphonates  via  Lewis Acid‐Catalyzed Hydrophosphonylation of Ketones | Zendy

Zhou Xin | Zendy; Liu Yanling | Zendy; Chang Lu | Zendy; Zhao Jiannan | Zendy; Shang Deju | Zendy; Liu Xiaohua | Zendy; Lin Lili | Zendy; Feng Xiaoming | Zendy

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Highly Efficient Synthesis of Quaternary α‐Hydroxy Phosphonates via Lewis Acid‐Catalyzed Hydrophosphonylation of Ketones

Author(s) -

Zhou Xin,

Liu Yanling,

Chang Lu,

Zhao Jiannan,

Shang Deju,

Liu Xiaohua,

Lin Lili,

Feng Xiaoming

Publication year - 2009

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200900531

Subject(s) - chemistry , lewis acids and bases , ketone , catalysis , enantioselective synthesis , organic chemistry , schiff base , titanium , lewis acid catalysis , combinatorial chemistry , polymer chemistry

A Lewis acid catalyst has been first applied to the hydrophosphonylation of ketones, giving the corresponding quaternary α‐hydroxy phosphonates in high yields (up to 98%). The present method was highly tolerable for functionalized ketones. Moreover, the first catalytic enantioselective hydrophosphonylation of an unactivated ketone was also realized by using a tridentate Schiff base‐titanium complex.

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