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Gold‐ and Silver‐Catalyzed Intramolecular Hydroamination of Terminal Alkynes: Water‐Triggered Chemo‐ and Regioselective Synthesis of Fused Tricyclic Xanthines
Author(s) -
Ye Deju,
Zhang Xu,
Zhou Yu,
Zhang Dengyou,
Zhang Lei,
Wang Hengshuai,
Jiang Hualiang,
Liu Hong
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900505
Subject(s) - hydroamination , chemistry , intramolecular force , regioselectivity , isomerization , catalysis , tricyclic , amination , combinatorial chemistry , organic chemistry
A simple, convenient and green synthetic approach to diverse fused tricyclic xanthines has been developed via gold(I) complex‐catalyzed intramolecular hydroamination or silver(I)‐catalyzed isomerization‐hydroamination of terminal alkynes under microwave irradiation in water. The first synthesis of N9‐annelated xanthines has also been reported.