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Palladium‐Catalyzed Decarboxylative sp ‐ sp 2 Cross‐Coupling Reactions of Aryl and Vinyl Halides and Triflates with α,β‐Ynoic Acids using Silver Oxide
Author(s) -
Kim Hyunseok,
Lee Phil Ho
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900502
Subject(s) - chemistry , palladium , aryl , catalysis , halide , decarboxylation , electrophile , oxide , silver oxide , coupling reaction , polymer chemistry , inorganic chemistry , organic chemistry , alkyl
Palladium‐catalyzed decarboxylative sp‐sp 2 cross‐coupling reactions of aryl and vinyl halides and triflates with α,β‐ynoic acids using silver oxide have been developed. A variety of α,β‐ynoic acids were readily decarboxylated in the presence of silver oxide and then, generated in situ , silver acetylides were coupled with electrophiles in the presence of a palladium(0) catalyst under neutral conditions, producing either symmetrical or unsymmetrical diarylacetylenes, arylalkylacetylenes and arylvinylacetylenes in good to excellent yields.