Novel Enantioselective Sequentially Rhodium(I)/BINAP‐ Catalyzed Cycloisomerization–Hydrogenation–Isomerization– Acetalization (CIHIA) | Zendy

Körber Nadine | Zendy; Rominger Frank | Zendy; Müller Thomas J. J. | Zendy

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Novel Enantioselective Sequentially Rhodium(I)/BINAP‐ Catalyzed Cycloisomerization–Hydrogenation–Isomerization– Acetalization (CIHIA)

Author(s) -

Körber Nadine,

Rominger Frank,

Müller Thomas J. J.

Publication year - 2009

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200900494

Subject(s) - cycloisomerization , rhodium , chemistry , isomerization , binap , enantioselective synthesis , catalysis , bicyclic molecule , combinatorial chemistry , organic chemistry , medicinal chemistry

Linear, easily accessible alkyl and (hetero)aryl‐substituted alkynyl allyl alcohols are readily and enantioselectively transformed into 2,7‐dioxabicyclo[3.2.1]octanes by a sequential rhodium‐catalyzed process. Based on the initial cycloisomerization, the in situ generated rhodium(I)‐BINAP complex enables a subsequent reduction with hydrogen and the transformation into bicyclic frameworks.

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