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Enantioselective Organocatalytic Conjugate Addition of Aldehydes to α,β‐Unsaturated Thiol Esters
Author(s) -
Zhu Shaolin,
Wang You,
Ma Dawei
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900449
Subject(s) - chemistry , enantioselective synthesis , conjugate , thiol , organocatalysis , organic chemistry , catalysis , silyl ether , michael reaction , silylation , addition reaction , ether , mathematical analysis , mathematics
The first example of an organocatalytic asymmetric Michael addition of aldehydes to α,β‐unsaturated thiol esters promoted by chiral diphenylprolinol silyl ether is presented. The reaction occurs with good yields, diastereoselectivity and excellent enantioselectivity.