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First Heterogeneous Ligand‐ and Salt‐Free Larock Indole Synthesis
Author(s) -
Batail Nelly,
Bendjeriou Anissa,
Lomberget Thierry,
Barret Roland,
Dufaud Véronique,
Djakovitch Laurent
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900386
Subject(s) - chemistry , palladium , indole test , catalysis , ligand (biochemistry) , benzofuran , salt (chemistry) , combinatorial chemistry , heterogeneous catalysis , organic chemistry , biochemistry , receptor
A new ligand‐ and salt‐free procedure using heterogeneous palladium catalysts for the Larock indole and benzofuran synthesis is reported. After optimisation of the reaction conditions, good to high isolated yields have been achieved for a variety of structures. Recycling studies have shown that the palladium catalysts can be readily recovered and reused. Reactions and recovery of the palladium catalysts can be carried out in the presence of air, without any particular precaution.

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