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Silver‐Catalyzed Intramolecular Cyclization of o ‐(1‐Alkynyl)benzamides: Efficient Synthesis of (1 H )‐Isochromen‐1‐imines
Author(s) -
Liu Guannan,
Zhou Yu,
Ye Deju,
Zhang Dengyou,
Ding Xiao,
Jiang Hualiang,
Liu Hong
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900381
Subject(s) - chemistry , moiety , intramolecular force , alkyne , amide , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry
An efficient avenue for the facile and atom‐economic synthesis of (1 H )‐isochromen‐1‐imines has been developed, and a broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields. Significantly, this is the first report of the synthesis of (1 H )‐isochromen‐1‐imines that involves a silver(I)‐catalyzed, regiocontrolled intramolecular addition of the carbonyl group of the amide moiety towards an alkyne.