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Synthesis of Biaryls and Aryl Ketones via Microwave‐Assisted Decarboxylative Cross‐Couplings
Author(s) -
Gooßen Lukas J.,
Zimmermann Bettina,
Linder Christophe,
Rodríguez Nuria,
Lange Paul P.,
Hartung Jens
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900337
Subject(s) - chemistry , aryl , bimetallic strip , catalysis , halide , microwave , combinatorial chemistry , decarboxylation , organic chemistry , alkyl , physics , quantum mechanics
A protocol for the microwave‐assisted decarboxylative cross‐couplings of carboxylic acid salts with aryl halides has been developed that allows the synthesis of various biaryls and aryl ketones in high yields. After careful adaptation of the bimetallic catalyst system and reaction conditions, these mechanistically complex transformations can now be performed within only five minutes in concentrated solution in a sealed vessel. This greatly simplified reaction protocol is ideally suited for applications in parallel synthesis and drug discovery.