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Palladium‐Catalyzed Isomerization of exo ‐Methylenic Allylic Alcohols
Author(s) -
Fordred Paul S.,
Niyadurupola D. Gangani,
Wisedale Richard,
Bull Steven D.
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900309
Subject(s) - isomerization , chemistry , allylic rearrangement , palladium , catalysis , alkene , medicinal chemistry , hydrogen , allylic alcohol , organic chemistry
Treatment of allylic alcohols containing a 1,1‐disubstituted alkene with a palladium catalyst and hydrogen gas (1 bar) results in facile isomerization to their corresponding trisubstituted ( E )‐allylic alcohols, along with small amounts of the corresponding hydrogenated products.