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Copper‐Catalyzed One‐Pot Synthesis of 2‐Alkylidene‐1,2,3,4‐ tetrahydropyrimidines
Author(s) -
Lu Wei,
Song Wangze,
Hong Deng,
Lu Ping,
Wang Yanguang
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900260
Subject(s) - chemistry , sulfonyl , catalysis , imine , copper , organic chemistry , one pot synthesis , combinatorial chemistry , alkyl
A one‐pot synthesis of N ‐sulfonyl‐2‐alkylidene‐1,2,3,4‐tetrahydropyrimidines via a highly selective and copper‐catalyzed multicomponent reaction of sulfonyl azides, terminal alkynes and α,β‐unsaturated imines has been developed. The α,β‐unsaturated imine substrates could be generated from amines and α,β‐unsaturated aldehydes in a one‐pot process. The procedure is concise, general and efficient.