A Direct Intermolecular Cross‐Benzoin Type Reaction: N‐Heterocyclic Carbene‐Catalyzed Coupling of Aromatic Aldehydes with Trifluoromethyl Ketones | Zendy

Enders Dieter | Zendy; Henseler Alexander | Zendy

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A Direct Intermolecular Cross‐Benzoin Type Reaction: N‐Heterocyclic Carbene‐Catalyzed Coupling of Aromatic Aldehydes with Trifluoromethyl Ketones

Author(s) -

Enders Dieter,

Henseler Alexander

Publication year - 2009

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200900247

Subject(s) - chemistry , carbene , trifluoromethyl , stereocenter , intermolecular force , benzoin , chemoselectivity , catalysis , umpolung , organic chemistry , medicinal chemistry , enantioselective synthesis , alkyl , molecule , nucleophile

A direct intermolecular cross‐benzoin‐type condensation catalyzed by an N‐heterocyclic carbene has been developed. The cross‐coupling of commercially available aromatic aldehydes and trifluoromethyl ketones results in α‐hydroxy‐α‐trifluoromethyl ketones bearing a quaternary stereocenter with excellent chemoselectivity and good to excellent yields.

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