Palladium‐Catalyzed Asymmetric Allylic Alkylation of 2,3‐Allenyl Acetates Using a Chiral Diaminophosphine Oxide | Zendy

Nemoto Tetsuhiro | Zendy; Kanematsu Mutsumi | Zendy; Tamura Shinji | Zendy; Hamada Yasumasa | Zendy

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Palladium‐Catalyzed Asymmetric Allylic Alkylation of 2,3‐Allenyl Acetates Using a Chiral Diaminophosphine Oxide

Author(s) -

Nemoto Tetsuhiro,

Kanematsu Mutsumi,

Tamura Shinji,

Hamada Yasumasa

Publication year - 2009

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200900151

Subject(s) - chemistry , enantioselective synthesis , tsuji–trost reaction , allylic rearrangement , catalysis , palladium , alkylation , yield (engineering) , organic chemistry , lithium (medication) , medicinal chemistry , medicine , materials science , endocrinology , metallurgy

An enantioselective synthesis of allenes through palladium‐catalyzed asymmetric allylic alkylation using a chiral diaminophosphine oxide is described. The asymmetric allylic alkylations proceeded in the presence of a catalytic amount of lithium acetate at 4 °C, affording the chiral allenes in excellent yield with up to 99% ee .

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