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Highly Enantioselective Organocatalytic syn ‐ and anti ‐Aldol Reactions in Aqueous Medium
Author(s) -
Raj Monika,
Parashari Gopal S.,
Singh Vinod K.
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900122
Subject(s) - chemistry , aldol reaction , enantioselective synthesis , triol , natural product , monosaccharide , organocatalysis , aqueous medium , organic chemistry , aqueous solution , catalysis , stereochemistry , diol
AbstractWe have synthesized chiral diamines that efficiently catalyze the syn ‐ and anti ‐aldol reactions in aqueous medium with high diastereo‐ and enantioselectivities. The product, thus obtained, was further reduced selectively to give syn ‐configured 1,2,3‐triol, an important subunit present in various monosaccharides and natural products such as (+)‐boronolide.