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Copper‐Catalyzed Conjugate Addition of Diboron Reagents to α,β‐Unsaturated Amides: Highly Reactive Copper‐1,2‐ Bis(diphenylphosphino)benzene Catalyst System
Author(s) -
Chea Heesung,
Sim HakSuk,
Yun Jaesook
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900040
Subject(s) - chemistry , catalysis , conjugate , copper , reagent , addition reaction , benzene , combinatorial chemistry , organic chemistry , polymer chemistry , medicinal chemistry , mathematical analysis , mathematics
AbstractAn efficient copper catalyst system for the β‐boration of α,β‐unsaturated amides has been developed. Copper‐bisphosphine complexes with small bite angles generate efficient catalyst systems for the successful conjugate addition of bis(pinacolato)diboron to a variety α,β‐unsaturated amides under mild conditions. This method was utilized in the formal synthesis of ( S )‐fluoxetine.