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Highly Functionalised Enantiopure 4‐Hydroxypyridine Derivatives by a Versatile Three‐Component Synthesis
Author(s) -
Eidamshaus Christian,
Reissig HansUlrich
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800789
Subject(s) - enantiopure drug , chemistry , pyridine , enantiomer , organic chemistry , tautomer , combinatorial chemistry , component (thermodynamics) , enantioselective synthesis , catalysis , physics , thermodynamics
The scope of a novel alkoxyallene‐based pyridine synthesis was expanded to enantiopure carboxylic acids and nitriles as starting materials. The enantiomeric purity of the chiral α‐secondary carboxylic acids and nitriles was completely preserved during this reaction sequence thus allowing the one‐pot preparation of a whole range of 4‐hydroxypyridines or their 4‐pyridinone tautomers in good yields.