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The Enantioselective Addition of Alkyne Nucleophiles to Carbonyl Groups
Author(s) -
Trost Barry M.,
Weiss Andrew H.
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800776
Subject(s) - enantioselective synthesis , chemistry , nucleophile , alkyne , organic chemistry , nucleophilic addition , combinatorial chemistry , catalysis
Over the past decade, large strides have been achieved in the invention of methods for the direct enantioselective addition of alkynes and metal alkynylide nucleophiles into prochiral aldehydes, ketones, and imines. This review highlights and compares the available methods for these transformations.