Premium
A Novel Cost‐Effective Thiourea Bifunctional Organocatalyst for Highly Enantioselective Alcoholysis of meso ‐Cyclic Anhydrides: Enhanced Enantioselectivity by Configuration Inversion
Author(s) -
Wang SuXi,
Chen FenEr
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800761
Subject(s) - chemistry , bifunctional , thiourea , enantioselective synthesis , organocatalysis , catalysis , organic chemistry , combinatorial chemistry , bifunctional catalyst
A novel inexpensive thiourea bifunctional organocatalyst which can promote the highly enantioselective (up to 95% ee ) alcoholysis of meso ‐cyclic anhydrides has been developed. Computational studies on the catalytic process as well as a synthetic application of this new catalyst are also presented.