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The Use of Copper Flow Reactor Technology for the Continuous Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles
Author(s) -
Bogdan Andrew R.,
Sach Neal W.
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800758
Subject(s) - chemistry , copper , cycloaddition , sodium azide , halide , azide , alkyl , 1,3 dipolar cycloaddition , catalysis , organic synthesis , continuous flow , flow chemistry , combinatorial chemistry , organic chemistry , physics , mechanics
A library of 1,4‐disubstituted 1,2,3‐triazoles was synthesized using a copper flow reactor. Organic azides, generated in situ from alkyl halides and sodium azide, were reacted with acetylenes using the copper‐catalyzed Huisgen 1,3‐dipolar cycloaddition. This process eliminates both the handling of organic azides and the need for additional copper catalyst and permits the facile preparation of numerous triazoles in a continuous flow process.