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Efficient Cross‐Coupling Reactions of Nitrogen Nucleophiles with Aryl Halides in Water
Author(s) -
Teo YongChua
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800746
Subject(s) - chemistry , nucleophile , aryl , halide , indole test , catalysis , yield (engineering) , nitrogen , pyrazole , chloride , benzamide , organic chemistry , combinatorial chemistry , alkyl , materials science , metallurgy
A facile and practical strategy has been developed for the N ‐arylation of nitrogen nucleophiles with aryl halides catalyzed by a combination of iron(III) chloride [FeCl 3 ] and dimethylethylenediamine (dmeda) in water. A variety of nitrogen nucleophiles including pyrazole, indole, 7‐azaindole and benzamide afforded the N ‐arylated products in the presence of the catalytic system (in up to 88% yield).