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Tandem Metal and Organocatalysis in Sequential Hydroformylation and Enantioselective Mannich Reactions
Author(s) -
Chercheja Serghei,
Rothenbücher Thomas,
Eilbracht Peter
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800720
Subject(s) - chemistry , hydroformylation , enantioselective synthesis , organocatalysis , tandem , catalysis , combinatorial chemistry , mannich reaction , stereoselectivity , organic chemistry , cascade reaction , rhodium , materials science , composite material
Metal‐catalysed hydroformylation is successfully combined with an organocatalysed stereoselective Mannich reaction in a tandem reaction sequence. This novel type of “tandem catalysis” allows access to complex molecular systems with high levels of enantioselectivity, using simple starting materials and an amino acid as the chiral catalyst.