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Trace Water‐Promoted Oxidation of Benzylic Alcohols with Molecular Oxygen Catalyzed by Vanadyl Sulfate and Sodium Nitrite under Mild Conditions
Author(s) -
Du Zhongtian,
Miao Hong,
Ma Hong,
Sun Zhiqiang,
Ma Jiping,
Xu Jie
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800700
Subject(s) - chemistry , catalysis , aldehyde , yield (engineering) , benzyl alcohol , sodium nitrite , alcohol , alcohol oxidation , molecular oxygen , nitrite , oxygen , sulfate , selectivity , inorganic chemistry , sodium sulfate , sodium , organic chemistry , materials science , nitrate , metallurgy
An inexpensive catalytic system consisting of vanadyl sulfate and sodium nitrite was developed for the oxidation of benzylic alcohols with molecular oxygen under mild conditions. Benzyl alcohols with various substitutions were efficiently converted to their corresponding aldehydes with high conversion and selectivity under 80 °C (e.g., 4‐nitrobenzyl alcohol was smoothly oxidized to 4‐nitrobenzyl aldehyde with 94% yield under 0.5 MPa of molecular oxygen). Halogen, noble metals, extra base or complicated ligands were avoided. Addition of a trace of water to this system before the reaction was crucial for the high efficiency.