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Enantioselective Synthesis of Chiral β‐Aryloxy Alcohols by Asymmetric Hydrogenation of α‐Aryloxy Aldehydes via Dynamic Kinetic Resolution
Author(s) -
Zhou ZhangTao,
Xie JianHua,
Zhou QiLin
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800634
Subject(s) - kinetic resolution , chemistry , enantioselective synthesis , diamine , catalysis , ruthenium , asymmetric hydrogenation , organic chemistry , optically active , chloride , combinatorial chemistry
A catalytic enantioselective hydrogenation of racemic α‐aryloxy aldehydes via dynamic kinetic resolution has been developed by using (diamine)(spirodiphosphine)ruthenium(II) chloride [RuCl 2 (SDPs)(diamine)] catalysts. Employing this new reaction system a variety of optically active β‐aryloxy primary alcohols were synthesized in high yields and moderate to good enantioselectivities.