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Iodine‐Catalyzed Suzuki–Miyaura Coupling Performed in Air
Author(s) -
Mao Jincheng,
Hua Qiongqiong,
Xie Guanlei,
Guo Jun,
Yao Zhigang,
Shi Daqing,
Ji Shunjun
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800624
Subject(s) - chemistry , phenylboronic acid , iodine , catalysis , polyethylene glycol , potassium carbonate , coupling (piping) , suzuki reaction , organic chemistry , palladium , mechanical engineering , engineering
uzuki‐type coupling reactions can be performed directly in air using a catalytic system composed of iodine, potassium carbonate, and polyethylene glycol 400 (I 2 /K 2 CO 3 /PEG‐400). Iodine was found to be an effective additive for accelerating these couplings. The methodology is also suitable for the coupling of ( E )‐ β ‐bromostyene with phenylboronic acid, with retention of the double bond geometry.