Premium
Highly Efficient Organocatalyzed Direct Asymmetric Aldol Reactions of Hydroxyacetone and Aldehydes
Author(s) -
Wu Xiaoyu,
Ma Zhixiong,
Ye Zhengqing,
Qian Shan,
Zhao Gang
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800558
Subject(s) - chemistry , aldol reaction , yield (engineering) , organocatalysis , catalysis , organic chemistry , enantioselective synthesis , aldehyde , materials science , metallurgy
Novel organocatalysts derived from L ‐threonine and L ‐leucine have been synthesized for catalyzing direct aldol reactions of hydroxycetone and unactivated aliphatic aldehydes with as low as 2 mol% loading of the catalyst, good to excellent yields and excellent enantioselectivities have been achieved for aliphatic aldehydes, whereas aromatic aldehydes yield only moderate enantioselectivities.