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Indium(III) Chloride‐Catalyzed Propargylation/Amination/Cycloisomerization Tandem Reaction: One‐Pot Synthesis of Highly Substituted Pyrroles from Propargylic Alcohols, 1,3‐Dicarbonyl Compounds and Primary Amines
Author(s) -
Liu Xiaotao,
Huang Lei,
Zheng Feijian,
Zhan Zhuangping
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800473
Subject(s) - cycloisomerization , chemistry , catalysis , amination , indium , tandem , primary (astronomy) , organic chemistry , chloride , one pot synthesis , combinatorial chemistry , materials science , physics , astronomy , composite material
A convenient one‐pot propargylation/amination/cycloisomerization tandem process has been developed for the synthesis of highly substituted pyrroles derivatives from propargylic alcohols, 1,3‐dicarbonyl compounds and primary amines using indium(III) chloride as a multifunctional catalyst. This method provides a flexible and rapid route to substituted pyrroles.