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A Direct Palladium‐Catalyzed Route to Selectively Substituted Carbazoles through Sequential CC and CN Bond Formation: Synthesis of Carbazomycin A
Author(s) -
Ca' Nicola Della,
Sassi Giovanni,
Catellani Marta
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800421
Subject(s) - chemistry , palladium , catalysis , norbornene , combinatorial chemistry , organic chemistry , copolymer , polymer
The present paper offers a synthetically simple one‐pot procedure for the catalytic preparation of the biologically interesting class of carbazoles. The new procedure is based on the combined catalysis of palladium and norbornene starting from o ‐substituted iodoarenes and N ‐sulfonylated or N ‐acetylated o ‐bromoanilines. A well‐known member of this class, carbazomycin A, has been successfully prepared.