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Exploring Structural Diversity in Ligand Design: The Aminoindanol Case
Author(s) -
RodríguezEscrich Sergi,
Solà Lluís,
Jimeno Ciril,
RodríguezEscrich Carles,
Pericàs Miquel A.
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800420
Subject(s) - enantiopure drug , chemistry , enantioselective synthesis , substituent , ligand (biochemistry) , bicyclic molecule , amination , stereochemistry , combinatorial chemistry , reductive amination , catalysis , organic chemistry , receptor , biochemistry
A series of enantiopure ligands based on the aminoindanol scaffold, but differing in regio‐ and stereochemistry has been synthesized. These ligands have been conveniently derivatized and their catalytic efficiency in different enantioselective reactions has been screened to determine privileged candidates with respect to regio‐ and stereochemistry for each considered process. The nature of the amino substituent has been optimized for specific applications and this has led to the development of an efficient method for the preparation of bulky bicyclic amines by reductive amination.