A Direct CC Cross‐Coupling of Alcohols at the β‐Position with Aldehydes under Co‐Promotion of Tris(triphenylphosphine)rhodium Chloride/Boron Trifuoride Etherate | Zendy

Zhang ShuYu | Zendy; Tu YongQiang | Zendy; Fan ChunAn | Zendy; Jiang YiJun | Zendy; Shi Lei | Zendy; Cao Ke | Zendy

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A Direct CC Cross‐Coupling of Alcohols at the β‐Position with Aldehydes under Co‐Promotion of Tris(triphenylphosphine)rhodium Chloride/Boron Trifuoride Etherate

Author(s) -

Zhang ShuYu,

Tu YongQiang,

Fan ChunAn,

Jiang YiJun,

Shi Lei,

Cao Ke

Publication year - 2008

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200800416

Subject(s) - chemistry , rhodium , triphenylphosphine , tris , boron , chloride , substrate (aquarium) , medicinal chemistry , coupling reaction , organic chemistry , catalysis , combinatorial chemistry , biochemistry , oceanography , geology

The novel tris(triphenylphosphine)rhodium chloride/boron trifuoride etherate [RhCl(PPh 3 ) 3 /BF 3 ⋅OEt 2 ] co‐promoted the CC cross‐coupling of tertiary alcohols at the β ‐ position with aldehydes. This reaction provides an efficient synthesis of either structurally diverse 1,3‐diols or polysubstituted tetrahydropyrans by controlling the substrate structures, and it could be developed to a practical synthetic method for numerous natural products and medicinally important compounds.

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