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A Direct CC Cross‐Coupling of Alcohols at the β‐Position with Aldehydes under Co‐Promotion of Tris(triphenylphosphine)rhodium Chloride/Boron Trifuoride Etherate
Author(s) -
Zhang ShuYu,
Tu YongQiang,
Fan ChunAn,
Jiang YiJun,
Shi Lei,
Cao Ke
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800416
Subject(s) - chemistry , rhodium , triphenylphosphine , tris , boron , chloride , substrate (aquarium) , medicinal chemistry , coupling reaction , organic chemistry , catalysis , combinatorial chemistry , biochemistry , oceanography , geology
The novel tris(triphenylphosphine)rhodium chloride/boron trifuoride etherate [RhCl(PPh 3 ) 3 /BF 3 ⋅OEt 2 ] co‐promoted the CC cross‐coupling of tertiary alcohols at the β ‐ position with aldehydes. This reaction provides an efficient synthesis of either structurally diverse 1,3‐diols or polysubstituted tetrahydropyrans by controlling the substrate structures, and it could be developed to a practical synthetic method for numerous natural products and medicinally important compounds.