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One‐Pot/Four‐Step/Palladium‐Catalyzed Synthesis of Indole Derivatives: The Combination of Heterogeneous and Homogeneous Systems
Author(s) -
Sakai Hayato,
Tsutsumi Ken,
Morimoto Tsumoru,
Kakiuchi Kiyomi
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800405
Subject(s) - chemistry , palladium , reagent , catalysis , indole test , homogeneous , yield (engineering) , combinatorial chemistry , homogeneous catalysis , organic chemistry , phase (matter) , physics , materials science , metallurgy , thermodynamics
One‐pot, four‐step syntheses of indoles using both solid‐supported heterogeneous and homogeneous palladium catalysts and reagents were carried out. Such a combination of these two‐phase catalysts and reagents causes a dramatic increase in yield, and it is a simple process. The presented methodology is effective for four‐step reactions to provide various functionalized indoles.