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Titanium(IV)/Tridentate BINOL Derivative as Catalyst for meso ‐Aziridine Ring‐Opening Reactions: High Enantioselectivity, Strong Positive Non‐Linear Effect and Structural Characterization
Author(s) -
Yu Rongmin,
Yamashita Yasuhiro,
Kobayashi Shū
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800402
Subject(s) - chemistry , aziridine , aniline , catalysis , ring (chemistry) , nucleophile , chiral lewis acid , lewis acids and bases , titanium , derivative (finance) , medicinal chemistry , organic chemistry , combinatorial chemistry , financial economics , economics
A titanium‐based chiral Lewis acid was found to be effective for the ring‐opening reactions of meso ‐aziridines with aniline nucleophiles. The products were generally isolated in high yields and with high to excellent enantioselectivity. The catalytic system was studied by X‐ray single crystal analysis. In experiments on non‐linear effects a strong non‐linear effect of the catalyst system was observed.