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Enantioselective Synthesis of Optically Active Alkanephos‐ phonates via Rhodium‐Catalyzed Asymmetric Hydrogenation of β‐Substituted α,β‐Unsaturated Phosphonates with Ferrocene‐Based Monophosphoramidite Ligands
Author(s) -
Duan ZhengChao,
Hu XiangPing,
Wang DaoYong,
Huang JiaDi,
Yu SaiBo,
Deng Jun,
Zheng Zhuo
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800388
Subject(s) - chemistry , rhodium , enantioselective synthesis , ferrocene , asymmetric hydrogenation , catalysis , optically active , ligand (biochemistry) , combinatorial chemistry , organic chemistry , electrochemistry , biochemistry , receptor , electrode
A series of chiral β‐substituted alkanephosphonates was synthesized in high enantioselectivities via the first rhodium‐catalyzed asymmetric hydrogenation of the corresponding β‐substituted‐α,β‐unsaturated phosphonates using a ferrocene‐derived monophosphoramidite ligand, with which up to 99.5% ee have been achieved for the hydrogenation of ( E )‐substrates and 98.0% ee for ( Z )‐substrates.