Iridium‐Catalyzed Enantioselective Allylic Alkylation using Chiral Phosphoramidite Ligand Bearing an Amide Moiety | Zendy

Onodera Gen | Zendy; Watabe Keijiro | Zendy; Matsubara Masaki | Zendy; Oda Kazuhiro | Zendy; Kezuka Satoko | Zendy; Takeuchi Ryo | Zendy

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Iridium‐Catalyzed Enantioselective Allylic Alkylation using Chiral Phosphoramidite Ligand Bearing an Amide Moiety

Author(s) -

Onodera Gen,

Watabe Keijiro,

Matsubara Masaki,

Oda Kazuhiro,

Kezuka Satoko,

Takeuchi Ryo

Publication year - 2008

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200800333

Subject(s) - chemistry , moiety , phosphoramidite , enantioselective synthesis , amide , tsuji–trost reaction , alkylation , lithium amide , iridium , ligand (biochemistry) , allylic rearrangement , catalysis , chiral ligand , organic chemistry , medicinal chemistry , combinatorial chemistry , dna , biochemistry , receptor , oligonucleotide

New chiral phosphoramidites with an amide moiety were used for iridium‐catalyzed asymmetric allylic alkylation reactions. The best results were obtained with a ligand bearing an oxazolidinone moiety. The reaction of cinnamyl acetate with diethyl sodiomalonate without the use of lithium chloride gave the branched product with 94% ee .

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