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Efficient Synthesis of Substituted Selenophenes Based on the First Palladium(0)‐Catalyzed Cross‐Coupling Reactions of Tetrabromoselenophene
Author(s) -
Tùng Đǎng Thanh,
Villinger Alexander,
Langer Peter
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800316
Subject(s) - sonogashira coupling , chemistry , regioselectivity , palladium , coupling reaction , aryl , combinatorial chemistry , catalysis , ligand (biochemistry) , suzuki reaction , tetra , organic chemistry , medicinal chemistry , biochemistry , alkyl , receptor
Regioselective Suzuki cross‐coupling reactions of tetrabromoselenophene allow a convenient synthesis of aryl‐substituted selenophenes. High yields were obtained using a novel biaryl‐monophosphine ligand. The first tetra(1‐alkynyl)selenophene was prepared in one step by a Sonogashira reaction of tetrabromoselenophene.