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Iminium Salt‐Catalysed Asymmetric Epoxidation using Hydrogen Peroxide as Stoichiometric Oxidant
Author(s) -
Page Philip C. Bulman,
Parker Phillip,
Rassias Gerasimos A.,
Buckley Benjamin R.,
Bethell Donald
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800303
Subject(s) - chemistry , iminium , hydrogen peroxide , stoichiometry , catalysis , salt (chemistry) , selectivity , catalytic cycle , peroxide , organic chemistry , combinatorial chemistry
Iminium salt organocatalysts can provide high selectivity and high efficiency in catalytic asymmetric epoxidation. They are normally used in conjunction with Oxone as the stoichiometric oxidant. Oxone, however, has limited stability and is insoluble in most organic solvents; we report here for the first time the development of a reaction system driven by hydrogen peroxide as the stoichiometric oxidant, involving an unusual double catalytic cycle.