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Access to Functionalized Isoquinoline N ‐Oxides via Sequential Electrophilic Cyclization/Cross‐Coupling Reactions
Author(s) -
Ding Qiuping,
Wu Jie
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800301
Subject(s) - isoquinoline , electrophile , chemistry , coupling (piping) , palladium , coupling reaction , catalysis , medicinal chemistry , combinatorial chemistry , organic chemistry , mechanical engineering , engineering
Electrophilic cyclization of 2‐alkynylbenzaldoximes with various electrophiles leads to the formation of 4‐iodoisoquinoline N ‐oxides or 4‐bromoisoquinoline N ‐oxides under mild conditions. The reaction can be transferred to highly functionalized isoquinoline N ‐oxides via palladium‐catalyzed cross‐coupling reactions.