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Proline‐Mediated Enantioselective Construction of Tetrahydropyridines via a Cascade Mannich‐Type/Intramolecular Cyclization Reaction
Author(s) -
Han RongGang,
Wang Yao,
Li YuYe,
Xu PengFei
Publication year - 2008
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800253
Subject(s) - chemistry , enantioselective synthesis , intramolecular force , aldimine , proline , cascade , mannich reaction , pyran , stereochemistry , cascade reaction , combinatorial chemistry , organic chemistry , catalysis , amino acid , chromatography , biochemistry
A highly diastereo‐ and enantioselective synthesis of 2,3‐disubstituted tetrahydropyridines was accomplished via a proline‐mediated cascade Mannich‐type/intramolecular cyclization reaction from preformed N ‐PMP ( p ‐methoxyphenyl) aldimines and inexpensive aqueous tetrahydro‐2 H ‐pyran‐2,6‐diol.