Proline‐Mediated Enantioselective Construction of Tetrahydropyridines  via  a Cascade Mannich‐Type/Intramolecular Cyclization Reaction | Zendy

Han RongGang | Zendy; Wang Yao | Zendy; Li YuYe | Zendy; Xu PengFei | Zendy

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Proline‐Mediated Enantioselective Construction of Tetrahydropyridines via a Cascade Mannich‐Type/Intramolecular Cyclization Reaction

Author(s) -

Han RongGang,

Wang Yao,

Li YuYe,

Xu PengFei

Publication year - 2008

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200800253

Subject(s) - chemistry , enantioselective synthesis , intramolecular force , aldimine , proline , cascade , mannich reaction , pyran , stereochemistry , cascade reaction , combinatorial chemistry , organic chemistry , catalysis , amino acid , chromatography , biochemistry

A highly diastereo‐ and enantioselective synthesis of 2,3‐disubstituted tetrahydropyridines was accomplished via a proline‐mediated cascade Mannich‐type/intramolecular cyclization reaction from preformed N ‐PMP ( p ‐methoxyphenyl) aldimines and inexpensive aqueous tetrahydro‐2 H ‐pyran‐2,6‐diol.

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